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Merck

AKR1C3

aldo-keto reductase family 1, member C3

Synonyms:
DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Species:
Human AKR1C3 (8644), Rat Akr1c3 (171516), dog AKR1C3 (497070), cow AKR1C3 (617917), cow AKR1C3 (782884), domestic cat AKR1C3 (100510801)
UniProtKB ID:
P42330, A8K2V0, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3
Gene ID:
  • Human(8644) Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • Rat(171516) aldo-keto reductase family 1, member C3
  • dog(497070) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
  • cow(617917) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
  • cow(782884) aldo-keto reductase family 1, member C1
  • domestic cat(100510801) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

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Antibodies

Product Number
Description
Species Reactivity
Application
A6229
Anti-AKR1C3 antibody, Mouse monoclonal, clone NP6.G6.A6, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry
microarray
western blot

Proteins

Product Number
Description
Species
F7807
Prostaglandin F Synthase human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human