P1093

Monoclonal Anti-Paxillin antibody produced in mouse

clone PXC-10, ascites fluid

• MDL-szám: MFCD00212475
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: ascites fluid
• antitest terméktípus: primary antibodies
• klón: PXC-10, monoclonal
• molekulatömeg: antigen 68-40 kDa
• tartalmaz: 15 mM sodium azide
• faj reaktivitás: bovine, rat, human, chicken, hamster
• technika/technikák: immunocytochemistry: suitable; microarray: suitable; western blot: 1:500 using a cultured human cell line extract
• izotípus: IgG1
• UniProt elérési szám: P49023
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... PXN(5829) ; rat ... Pxn(360820)

Leírás

Általános leírás

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

Egyediség

Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

Immunogen

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

Alkalmazás

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

Biokémiai/fiziológiai hatások

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable