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  • Bioresorbable drug-eluting magnesium-alloy scaffold for treatment of coronary artery disease.

Bioresorbable drug-eluting magnesium-alloy scaffold for treatment of coronary artery disease.

International journal of molecular sciences (2013-12-20)
Carlos M Campos, Takashi Muramatsu, Javaid Iqbal, Ya-Jun Zhang, Yoshinobu Onuma, Hector M Garcia-Garcia, Michael Haude, Pedro A Lemos, Boris Warnack, Patrick W Serruys
ABSTRACT

The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Magnesium, ReagentPlus®, ribbon, ≥99% trace metals basis
Sigma-Aldrich
Magnesium, chips, 6-35 mesh, 99.98% trace metals basis
Sigma-Aldrich
Magnesium, purum, for Grignard reactions, ≥99.5%, turnings
Sigma-Aldrich
Magnesium, powder, ≥99%
Sigma-Aldrich
Magnesium, ribbon, ≥99.0% Mg basis
Sigma-Aldrich
Magnesium, grit, ≥99.0% (KT)
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Magnesium, dendritic pieces, purified by distillation, 99.998% trace metals basis
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Magnesium, turnings, reagent grade, 98%
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Magnesium preparation, Highly Reactive Rieke® Metal, suspension, 2.5 g in THF
Sigma-Aldrich
Magnesium, 20-230 mesh, reagent grade, 98%
Sigma-Aldrich
Magnesium, rod, diam. 6 mm, ≥99.9% trace metals basis
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Magnesium, turnings, 5-25 mm, 99.95% trace metals basis
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Magnesium, in a Sure/Seal bottle, turnings, 37.5 mmol
Sigma-Aldrich
Magnesium, in a Sure/Seal bottle, turnings, anhydrous tetrahydrofuran 37.5 mmol
Sigma-Aldrich
Magnesium, wire, 127 μm diameter, 99.9% trace metals basis
Magnesium, wire reel, 0.1m, diameter 0.4mm, as drawn, 99.9+%
Magnesium, wire reel, 1m, diameter 1.1mm, as drawn, 99.9+%
Magnesium, wire reel, 2m, diameter 0.125mm, as drawn, 99.9+%
Magnesium, microfoil, 25x25mm, thinness 1.0μm, specific density 174μg/cm2, 6 micron aluminum permanent support, 99.9%
Magnesium, wire reel, 0.1m, diameter 1.0mm, as drawn, 99.9+%
Magnesium, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.9+%
Magnesium, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.9+%
Magnesium, wire reel, 1m, diameter 1.0mm, as drawn, 99.9+%
Magnesium, wire reel, 0.1m, diameter 1.1mm, as drawn, 99.9+%
Magnesium, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.9+%
Magnesium, wire reel, 2m, diameter 0.4mm, as drawn, 99.9+%
Magnesium, wire reel, 0.5m, diameter 0.4mm, as drawn, 99.9+%
Magnesium, wire reel, 2m, diameter 0.5mm, as drawn, 99.9+%
Magnesium, microfoil, 50x50mm, thinness 1.0μm, specific density 174μg/cm2, 6 micron aluminum permanent support, 99.9%
Magnesium, microleaf, 50x50mm, thinness 1.0μm, specific density 174μg/cm2, removable support, 99.9%