- Preparation of highly functionalized alkylzinc halides from alkyl bromides using Mg, ZnCl2 and LiCl.
Preparation of highly functionalized alkylzinc halides from alkyl bromides using Mg, ZnCl2 and LiCl.
Chemical communications (Cambridge, England) (2010-04-10)
Tobias D Blümke, Fabian M Piller, Paul Knochel
PMID20379592
ABSTRACT
Alkyl bromides bearing various functional groups are smoothly converted to functionalized alkylzinc reagents by the direct insertion of magnesium in the presence of LiCl and ZnCl(2).
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Copper(I) cyanide di(lithium chloride) complex solution, in anhydrous tetrahydrofuran