[Effect of various factors on the absorption of dimedrol, diprazine (pipolphen) and suprastin on rat small intestine in vitro].

In the experiments on male albino rats absorption of dimedrol, pipolphen and suprastin from the small intestine was studied in vitro by the method of "turned sacks". It was shown that immunization of the animals with ovalbumin in combination with Freund's incomplete adjuvant does not influence significantly absorption of the antihistaminic agents in the rat small intestine in vitro. During anaphylactic shock absorption of pipolphen and to a lesser degree of suprastin tends to increase. The structure of the absorbing surface of the intestinal mucosal epithelium is of importance for absorption of dimedrol and to a lesser degree of pipolphen. Absorption of the antihistaminic agents in the rat small intestine in vitro depends on the activity of the drug metabolizing enzymes that especially distinctly shows up for pipolphen. Induction of the metabolizing enzymes by phenobarbital contributes to an active elimination of the agents from the incubation medium. Absorption of dimedrol and suprastin is implemented through an active transport whose energy supply for dimedrol is related to a greater extent to anaerobic processes of oxidation and for suprastin both to aerobic and anaerobic processes.