Skip to Content
Merck
  • Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes.

Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes.

Organic letters (2007-11-14)
Sarathy Kesavan, James S Panek, John A Porco
ABSTRACT

Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive cyclopropanation-Cope rearrangement affords novel chemotypes including spiroindane frameworks.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indan, 95%
Supelco
Indan, analytical standard