SLC4A1
solute carrier family 4 (anion exchanger), member 1
Synonyms:
AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR
Species:
Human SLC4A1 (6521), Mouse Slc4a1 (20533), Rat Slc4a1 (24779), domestic cat SLC4A1 (101099413), Domestic Rabbit SLC4A1 (100349024), dog SLC4A1 (490939), sheep SLC4A1 (101114627), cow SLC4A1 (286817), chicken SLC4A1 (396532), domestic guinea pig Slc4a1 (100728784) ...More
UniProtKB ID:
Gene ID:
- Human(6521) Summary: The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]
- Mouse(20533) solute carrier family 4 (anion exchanger), member 1
- Rat(24779) solute carrier family 4 (anion exchanger), member 1
- domestic cat(101099413) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- Domestic Rabbit(100349024) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- dog(490939) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- sheep(101114627) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- cow(286817) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- chicken(396532) solute carrier family 4, anion exchanger, member 1
- domestic guinea pig(100728784) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- naked mole-rat(101719082) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- Horse(100009691) solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Band 3 antibody produced in mouse, clone BIII-136, ascites fluid,
Species Reactivity
human
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-SLC4A1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Anion Exchanger 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
western blot
western blot
Anti-Band 3 antibody, Mouse monoclonal, clone BIII-136, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Monoclonal Anti-SLC4A1 antibody produced in mouse, clone 2D5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot