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Merck

IGF1R

insulin-like growth factor 1 receptor

Synonyms:
CD221, IGFIR, IGFR, JTK13
Species:
Human IGF1R (3480), Mouse Igf1r (16001), Rat Igf1r (25718), domestic guinea pig Igf1r (100734840), chicken IGF1R (395889), naked mole-rat Igf1r (101710224), Horse IGF1R (100055698), domestic cat IGF1R (100500937), cow IGF1R (281848), dog IGF1R (442951)
UniProtKB ID:
P08069, B1B5Y2, Q14CV2, Q9UCC0
Gene ID:
  • Human(3480) Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
  • Mouse(16001) insulin-like growth factor I receptor
  • Rat(25718) insulin-like growth factor 1 receptor
  • domestic guinea pig(100734840) insulin-like growth factor 1 receptor
  • chicken(395889) insulin-like growth factor 1 receptor
  • naked mole-rat(101710224) insulin-like growth factor 1 receptor
  • Horse(100055698) insulin-like growth factor 1 receptor
  • domestic cat(100500937) insulin-like growth factor 1 receptor
  • cow(281848) insulin-like growth factor 1 receptor
  • dog(442951) insulin-like growth factor 1 receptor
  • sheep(443002) insulin-like growth factor 1 receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

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ELISA

Product Number
Description
Species
RAB0230
Human IGF-I R ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
05-1106
Anti-IGF-IR Antibody, β-subunit, clone 1-2, clone 1-2, from mouse, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
05-1571
Anti-IGF-1R Antibody, clone 24-57, clone 24-57, from mouse,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
SAB2101136
Anti-IGF1R antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, pig, sheep
Application
immunofluorescence
immunohistochemistry
western blot
SAB4501523
Anti-IGF1R antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
SAB4300548
Anti-IGF1R (Ab-1280) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
T9576
Picropodophyllotoxin, ≥96% (HPLC), powder,
Species
human
T7697
I-OMe-Tyrphostin AG 538, solid,
Species
human

Proteins

Product Number
Description
Species
14-465-M
IGF-IR (δ1-958) Protein, active, 20 µg, Active, N-terminal His6-tagged, recombinant human IGF-IR residues 959-end, for use in Kinase Assays.,
Species
human
I4657
Insulin-like Growth Factor-I Receptor human, ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
human
S1820
Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt, ≥98% (HPLC), lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
EHU028861
MISSION® esiRNA, targeting human IGF1R,
Species
human
EMU017201
MISSION® esiRNA, targeting mouse Igf1r,
Species
mouse

Small Molecule - Substrate

Product Number
Description
Species
12-527
IGF-IRtide, Substrate for in vitro IGF-1R kinase assays.,
Species
human