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Merck

CXCR2

chemokine (C-X-C motif) receptor 2

Synonyms:
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Species:
Human CXCR2 (3579), Mouse Cxcr2 (12765), Rat Cxcr2 (29385), cow CXCR2 (782719), sheep CXCR2 (101110214), naked mole-rat Cxcr2 (101712581), domestic cat CXCR2 (101085396), dog CXCR2 (478905), chicken CXCR2 (430652), Domestic Rabbit CXCR2 (100328627) ...More
UniProtKB ID:
P25025, Q8IUZ1, Q9P2T6, Q9P2T7
Gene ID:
  • Human(3579) Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
  • Mouse(12765) chemokine (C-X-C motif) receptor 2
  • Rat(29385) chemokine (C-X-C motif) receptor 2
  • cow(782719) chemokine (C-X-C motif) receptor 2
  • sheep(101110214) chemokine (C-X-C motif) receptor 2
  • naked mole-rat(101712581) chemokine (C-X-C motif) receptor 2
  • domestic cat(101085396) chemokine (C-X-C motif) receptor 2
  • dog(478905) interleukin 8 receptor, beta
  • chicken(430652) chemokine (C-X-C motif) receptor 2
  • Domestic Rabbit(100328627) chemokine (C-X-C motif) receptor 2
  • cow(281863) interleukin 8 receptor, beta
  • domestic guinea pig(100379569) chemokine (C-X-C motif) receptor 2

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA031999
Anti-CXCR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
SAB1406027
Anti-CXCR2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB4504243
Anti-phospho-IL-8R β/CDw128 β (pSer347) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4501544
Anti-IL-8R β antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
ZRB2964
Anti-CXCR2/IL-8RB Antibody, clone 2D18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot