[Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound].

To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets. Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen. Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.