- A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant.
A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant.
Bioorganic & medicinal chemistry letters (2012-09-22)
Zhisheng Wu, Xuanjun Wu, Yuhui Yang, Ting-bin Wen, Shoufa Han
PMID22995618
ABSTRACT
N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.
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