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Merck

Coenzyme A: back in action.

Progress in lipid research (2005-05-17)
Roberta Leonardi, Yong-Mei Zhang, Charles O Rock, Suzanne Jackowski
ABSTRACT

Coenzyme A (CoA) is a ubiquitous essential cofactor that plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids. In the last few years, all of the genes encoding the CoA biosynthetic enzymes have been identified and the structures of several proteins in the pathway have been determined. CoA is assembled in five steps from pantothenic acid and pathway intermediates are common to both prokaryotes and eukaryotes. In spite of the identical biochemistry, remarkable sequence differences among some of the prokaryotic and eukaryotic enzymes have been revealed by comparative genomics. Renewed interest in CoA has arisen from the realization that the biosynthetic pathway is a target for antibacterial drug discovery and from the unexpected association of a human neurodegenerative disorder with mutations in pantothenate kinase. The purpose of this review is to integrate previous knowledge with the most recent findings in the genetics, enzymology and regulation of CoA biosynthesis in bacteria, plants and mammals.

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Sigma-Aldrich
Coenzyme A, oxidized lithium salt, ≥85%
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Sigma-Aldrich
Coenzyme A, Trilithium Salt, Coenzyme A, Trilithium Salt, CAS 18439-24-2, serves as a cofactor in enzymatic acetyl transfer reactions.
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Avanti
Coenzyme A (Li salt), Avanti Research - A Croda Brand 870701P, powder
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