Skip to Content
Merck
All Photos(5)

Key Documents

View All Documentation

D8161

Sigma-Aldrich

1,4-Dithioerythritol

BioReagent, for molecular biology, ≥99.0%

Synonym(s):

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

Sign Into View Organizational & Contract Pricing
All Photos(5)

About This Item

Linear Formula:
HSCH2CH(OH)CH(OH)CH2SH
CAS Number:
6892-68-8
Molecular Weight:
154.25
Beilstein:
1719756
EC Number:
229-998-8
MDL number:
MFCD00063750
UNSPSC Code:
12161504
PubChem Substance ID:
24894196
NACRES:
NA.31

grade

for molecular biology

product line

BioReagent

Assay

≥99.0%

form

powder

reaction suitability

reagent type: reductant

pH

4.5-6.5 (25 °C, 15.4 g/L)

mp

82-84 °C (lit.)

solubility

water: 50 mg/mL

foreign activity

DNase, Exonuclease detection, RNase, and protease, none detected

storage temp.

2-8°C

SMILES string

O[C@@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

InChI key

VHJLVAABSRFDPM-ZXZARUISSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.
reducing reagent

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ta-Lun Kao et al.
Theranostics, 8(10), 2672-2682 (2018-05-19)
Background and Aims: Improving liver regeneration (LR) capacity and thereby liver function reserve is a critical bridging strategy for managing liver failure patients. Since estrogen signaling may participate in LR, our aim was to characterize the roles of ERα and
C Pasquali et al.
Electrophoresis, 18(14), 2573-2581 (1998-04-04)
Electrophoretic techniques, and especially two-dimensional gel electrophoresis (2-DE), have provided an indispensable set of tools for the separation of complex protein mixtures as well as for the identification of protein-protein interactions. Nevertheless, after its introduction more than twenty years ago
I Fialka et al.
Electrophoresis, 18(14), 2582-2590 (1998-04-04)
Protein targeting and sorting is accomplished by complex vesicular transport processes that are tightly regulated within a cell. This is especially important for epithelial cells because correct delivery of newly synthesized proteins as well as recycling and sorting of internalized
Yang-Rae Kim et al.
ACS applied materials & interfaces, 2(1), 292-295 (2010-04-02)
A strategy for the rational design of a novel colorimetric sensor based on dithioerythritol-modified gold nanoparticles for the selective recognition of Hg2+ in aqueous media is presented. This approach relies on the combination of gold nanoparticles with Hg2+ through sulfur-Hg2+-sulfur
András Kolozsi et al.
Inorganic chemistry, 47(9), 3832-3840 (2008-04-03)
The aqueous solutions of arsenous acid with the meso and racemic forms of 1,4-dithiol-butane-2,3-diol, namely, dithioerythritol (dte) and dithiothreitol (dtt), respectively, were titrated pH-metrically in different molar ratios. The p K a values determined for As(OH) 3, and dtt were
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service