A5922

Amifostine trihydrate

≥97% (TLC), powder

• Synonym(s): 2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
• Empirical Formula (Hill Notation): C₅H₁₅N₂O₃PS · 3 H₂O
• CAS Number: 112901-68-5
• Molecular Weight: 268.27
• MDL number: MFCD00453866
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278231
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥97% (TLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: OP(SCCNCCCN)(O)=O.O.O.O
• InChI: 1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
• InChI key: TXQPXJKRNHJWAX-UHFFFAOYSA-N

Description

Application

Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Biochem/physiol Actions

Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves