07-122
Anti-Kalirin Antibody
Upstate®, from rabbit
Synonym(s):
Anti-ARHGEF24, Anti-CHDS5, Anti-DUET, Anti-DUO, Anti-HAPIP, Anti-TRAD
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... KALRN(8997)
Related Categories
Specificity
Kalirin; does not cross react with Trio
Immunogen
GST fusion protein corresponding to residues 517-976 of rat Kalirin, cleaved with thrombin to remove the GST moiety; referred to as JH2582
Application
Anti-Kalirin Antibody is an antibody against Kalirin for use in IP, WB & IC.
Research Category
Signaling
Signaling
Research Sub Category
G-proteins
Cytoskeletal Signaling
G-proteins
Cytoskeletal Signaling
Quality
routinely evaluated by immunoblot on RIPA lysates from rat brain microsomal protein preparation; long exposure times may be required
Target description
190, 115, 370 and 420kDa isoforms
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30%
Format: Purified
Protein A chromatography
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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R E Mains et al.
The Journal of biological chemistry, 274(5), 2929-2937 (1999-01-23)
The production and regulated secretion of bioactive peptides require a series of lumenal enzymes to convert inactive precursors into bioactive peptides plus several cytosolic proteins to govern granule formation, maturation, translocation, and exocytosis. Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential
Kalirin inhibition of inducible nitric-oxide synthase.
Ratovitski, E A, et al.
The Journal of Biological Chemistry, 274, 993-999 (1999)
P Penzes et al.
The Journal of biological chemistry, 275(9), 6395-6403 (2000-02-29)
Communication between membranes and the actin cytoskeleton is an important aspect of neuronal function. Regulators of actin cytoskeletal dynamics include the Rho-like small GTP-binding proteins and their exchange factors. Kalirin is a brain-specific protein, first identified through its interaction with
The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang, S; Eleniste, PP; Wayakanon, K; Mandela, P; Eipper, BA; Mains, RE; Allen, MR; Bruzzaniti, A
Bone null
Deepak P Srivastava et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11864-11878 (2012-08-24)
Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and
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