764248

Amino-PEG4-alkyne

• Synonym(s): 3,6,9,12-Tetraoxapentadec-14-yn-1-amine, Acetylene-PEG4-amine, H₂N-PEG4-propyne, Triethylene glycol 2-aminoethyl propargyl ether
• Empirical Formula (Hill Notation): C₁₁H₂₁NO₄
• CAS Number: 1013921-36-2
• Molecular Weight: 231.29
• MDL number: MFCD22380736
• UNSPSC Code: 12352106
• PubChem Substance ID: 329767109
• NACRES: NA.22

Properties

• form: liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• functional group: alkyne; amine
• storage temp.: −20°C
• SMILES string: NCCOCCOCCOCCOCC#C
• InChI: 1S/C11H21NO4/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1H,3-12H2
• InChI key: QDLPAHLHHBCWOW-UHFFFAOYSA-N

Description

Application

Heterobifunctional linker enabling the connection of an azide containing compound or biomolecule to one with a carboxylic acid. The amine group can be linked to a carboxylic acid through standard coupling procedures (EDC, product #39391, etc...) and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Amino-PEG4-alkyne may be used to synthesize alkynyl-functionalized iron oxide nanoparticles (IONPs) for preparing glycopolymer-based iron oxide nanoparticles (GIONs) for potential bioscience applications.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable