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Merck
  • A new lipid excipient, phosphorylated tocopherol mixture, TPM enhances the solubilisation and oral bioavailability of poorly water soluble CoQ

A new lipid excipient, phosphorylated tocopherol mixture, TPM enhances the solubilisation and oral bioavailability of poorly water soluble CoQ

Journal of controlled release : official journal of the Controlled Release Society (2017-11-04)
Anna C Pham, Paul Gavin, Roksan Libinaki, Gisela Ramirez, Ben J Boyd
RESUMEN

Phosphorylated tocopherols are a new class of lipid excipients that have demonstrated potential in pharmaceutical applications. Their ability to solubilise poorly water soluble drugs indicates their potential utility in improving bioavailability of drugs where solubility limits their bioavailability. In this study a commercial mixture of phosphorylated tocopherols, TPM was combined with medium chain triglyceride (MCT) as a formulation for CoQ

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Sigma-Aldrich
4-Bromophenylboronic acid, ≥95.0%