- Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.
Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.
ACS chemical biology (2017-05-10)
Hélène Muller-Steffner, Sylvain A Jacques, Isabelle Kuhn, Michael D Schultz, Davide Botta, Paul Osswald, Clarisse Maechling, Frances E Lund, Esther Kellenberger
PMID28481502
RESUMEN
SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite that is one of the major agents of the neglected tropical disease schistosomiasis. Recently, we identified aroylhydrazone derivatives capable of inhibiting the recombinant form of the enzyme with variable potency (IC
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