- Chebulagic acid is a potent alpha-glucosidase inhibitor.
Chebulagic acid is a potent alpha-glucosidase inhibitor.
Bioscience, biotechnology, and biochemistry (2008-02-08)
Hong Gao, Yi-Na Huang, Bo Gao, Jun Kawabata
PMID18256469
RESUMEN
Chebulagic acid, isolated form Terminalia chebula Retz, proved to be a reversible and non-competitive inhibitor of maltase with a K(i) value of 6.6 muM. The inhibitory influence of chebulagic acid on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex. The magnitude of alpha-glucosidase inhibition by chebulagic acid was greatly affected by its origin. These results show a use for chebulagic acid in managing type-2 diabetes.
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