- Lithiation of TMEDA and its higher homologous TEEDA: understanding observed alpha- and beta-deprotonation.
Lithiation of TMEDA and its higher homologous TEEDA: understanding observed alpha- and beta-deprotonation.
Journal of the American Chemical Society (2008-10-10)
Viktoria H Gessner, Carsten Strohmann
PMID18842047
RESUMEN
TMEDA and its ethyl-substituted analogue, TEEDA, show a different behavior toward the deprotonation with lithiumalkyls. While TMEDA mainly undergoes alpha-lithiation of its methyl group, TEEDA shows selective beta-lithiation with following elimination of ethene. The crystal structure of the monomeric intermediate of this beta-lithiation, tBuLi.TEEDA, and theoretical studies indicate kinetic favoritism for the beta-lithiation.
MATERIALES
Referencia del producto
Marca
Descripción del producto