- [Radiation protective effect of beta-ketoanalogs of hydroxyphenyl ethanolamines].
[Radiation protective effect of beta-ketoanalogs of hydroxyphenyl ethanolamines].
Radiatsionnaia biologiia, radioecologiia (1998-02-19)
V I Kulinskiĭ, V G Iashunskiĭ, A D Klimova, T V Alpatova
PMID9467647
RESUMEN
Experiments are carried out on 3400 mice, irradiated in dose 8 Gy (LD97/30). beta-Ketoanalogs of adrenaline (adrenalone, 50-150 mumol/kg), m,p-dipivaloyladrenaline (20 mumol/kg) and phenylephrine (but at 2070 mumol/kg) have the high radioprotective effect (survival is 60-100%), beta-ketoanalogs of isoprenaline and m-benzoylphenylephrine have the middle RPE (50-60%). Their effective doses (except dipivaloyladrenalone) are considerably bigger (in 9-76 times), than beta-hydroxysubstances doses, but the toxicity of benzoylphenylephrone, dipivaloyladrenalone and especially adrenalone is by far lower (consequently in 3, 8, 2, 7 and 136 times). Therapeutic indexes of beta-ketosubstances achieve 35-100.
MATERIALES
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Sigma-Aldrich
3′,4′-Dihydroxy-2-(methylamino)acetophenone hydrochloride, ≥98.0% (calc. based on dry substance, AT)
Dipivefrine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Dipivefrine for system suitability, European Pharmacopoeia (EP) Reference Standard