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Merck

Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules.

Molecular diversity (2012-05-16)
Abha Chaudhary, Pralay Das, Awanish Mishra, Pushpinder Kaur, Bikram Singh, Rajesh K Goel
RESUMEN

A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.

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Sigma-Aldrich
Vinyl bromide, 98%
Sigma-Aldrich
Vinyl bromide solution, 1.0 M in THF