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First prebiotic generation of a ribonucleotide from adenine, D-ribose and trimetaphosphate.

Chemical communications (Cambridge, England) (2011-02-10)
Graziano Baccolini, Carla Boga, Gabriele Micheletti
RESUMEN

Adenosine monophosphate isomers are obtained by self-assembling of adenine, D-ribose and trimetaphosphate in aqueous solution in good yields. This generation of a ribonucleotide from its three molecular components occurs in a one-pot reaction at room temperature for about 30-40 days and with high chemio-, regio-, and stereo-selectivity. Similar results are obtained with guanine. A mechanism is also proposed.

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Trisodium trimetaphosphate, ≥95%