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A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin.

Carbohydrate research (2011-02-08)
Yongjiang Gan, Yimin Zhang, Chuanhao Xiao, Chunyan Zhou, Yucang Zhao
RESUMEN

A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, (1)H NMR, and (13)C NMR.

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Sigma-Aldrich
Dimethyl carbonate, anhydrous, ≥99%
Sigma-Aldrich
Dimethyl carbonate, ReagentPlus®, 99%