- Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.
Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.
Organic & biomolecular chemistry (2009-10-02)
Benjamin Pluvinage, Mariana G Ghinet, Ryszard Brzezinski, Alisdair B Boraston, Keith A Stubbs
PMID19795054
RESUMEN
The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.
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