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Sigma-Aldrich

N,N-Dimethyldodecylamine N-oxide

BioXtra, ≥99.0% (NT)

Synonym(s):

DDAO, LDAO, Lauryldimethylamine N-oxide

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About This Item

Linear Formula:
CH3(CH2)11N(O)(CH3)2
CAS Number:
1643-20-5
Molecular Weight:
229.40
Beilstein:
1769927
EC Number:
216-700-6
MDL number:
MFCD00002049
UNSPSC Code:
12161902
PubChem Substance ID:
57649946
NACRES:
NA.26

description

non-ionic

Quality Level

200

product line

BioXtra

Assay

≥99.0% (NT)

form

powder

mol wt

229.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.03% peroxides (as H2O2)

CMC

1-2 mM

mp

132-133 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤100 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCC[N+](C)(C)[O-]

InChI

1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

InChI key

SYELZBGXAIXKHU-UHFFFAOYSA-N

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General description

N,N-Dimethyldodecylamine N-oxide is a non-denaturing zwitterionic surfactant with a critical micelle concentration (CMC) of approximately 1 mM. It is used to solubilize proteins and to study the conformation and molecular interactions of macromolecules.

Application

N,N-Dimethyldodecylamine N-oxide has been used in the cell lysis and resuspension of cell pellets for western blot analysis.

Signal Word

Danger

Hazard Statements

H302,H315,H318,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eugenio Daviso et al.
Journal of the American Chemical Society, 133(42), 16754-16757 (2011-10-04)
Several techniques rely on electron-nuclear interactions to boost the polarization of nuclear spins in the solid phase. Averaging out of anisotropic interactions as a result of molecular tumbling strongly reduces the applicability of such hyperpolarization approaches in liquids. Here we
Gerardo Palazzo et al.
Biochimica et biophysica acta, 1804(1), 137-146 (2009-09-30)
We report on the response of reaction center (RC) from Rhodobacter sphaeroides (an archetype of membrane proteins) to the exposure at high temperature. The RCs have been solubilized in aqueous solution of the detergent N,N-dimethyldodecylamine-N-oxide (LDAO). Changes in the protein
J Karlovská et al.
Biophysical chemistry, 119(1), 69-77 (2005-10-15)
Sarcoplasmic reticulum Ca-transporting ATPase (EC 3.6.1.38) was isolated from rabbit white muscle, purified and reconstituted into vesicles of synthetic diacylphosphatidylcholines with monounsaturated acyl chains using the cholate dilution method. In fluid bilayers at 37 degrees C, the specific activity of
Stefanie Keis et al.
Journal of bacteriology, 188(11), 3796-3804 (2006-05-19)
The F(1)F(o)-ATP synthases of alkaliphilic bacteria exhibit latent ATPase activity, and for the thermoalkaliphile Bacillus sp. strain TA2.A1, this activity is intrinsic to the F(1) moiety. To study the mechanism of ATPase inhibition, we developed a heterologous expression system in
Rie Kakehashi et al.
Journal of colloid and interface science, 289(2), 498-503 (2005-08-23)
In the hydrogen ion titration of micelles, the degree of ionization of the micelle at a given pH has to be evaluated to obtain a pKa value of micelles (Ka being the proton dissociation constant) at the pH. We compared
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