403644

N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)

96%

• Synonym(s): 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, Comins’ Reagent
• Empirical Formula (Hill Notation): C₇H₃ClF₆N₂O₄S₂
• CAS Number: 145100-51-2
• Molecular Weight: 392.68
• Beilstein: 5833971
• MDL number: MFCD00191833
• UNSPSC Code: 12352005
• PubChem Substance ID: 24865208
• NACRES: NA.22

Properties

• Assay: 96%
• form: solid
• mp: 45-47 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)S(=O)(=O)N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F
• InChI: 1S/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H
• InChI key: TUFGVZMNGTYAQD-UHFFFAOYSA-N

Description

Application

Provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates.

Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves