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Merck

Phosphatidylserine and the human brain.

Nutrition (Burbank, Los Angeles County, Calif.) (2015-05-03)
Michael J Glade, Kyl Smith
ABSTRACT

The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function. A scientific literature search was conducted on MEDLINE for relevant articles regarding PS and the human brain published before June 2014. Additional publications were identified from references provided in original papers; 127 articles were selected for inclusion in this review. A large body of scientific evidence describes the interactions among PS, cognitive activity, cognitive aging, and retention of cognitive functioning ability. Phosphatidylserine is required for healthy nerve cell membranes and myelin. Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission. Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes.

MATERIALS
Product Number
Brand
Product Description

Avanti
18:1-12:0 NBD PS, Avanti Research - A Croda Brand 810195C
Avanti
18:1-12:0 NBD PS, Avanti Research - A Croda Brand 810195P, powder
Avanti
16:0-18:2 PS, 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
16:0-18:2 PS, 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
Avanti
06:0 PS, 1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform
Avanti
17:0-20:4 PS, Avanti Research - A Croda Brand LM1302, methanol solution
Avanti
15:0-18:1-d7-PS, Avanti Research - A Croda Brand
Avanti
16:0-12:0 NBD PS, Avanti Research - A Croda Brand 810193C
Avanti
16:0-06:0 NBD PS, Avanti Research - A Croda Brand 810192P, powder
Avanti
16:0-06:0 NBD PS, Avanti Research - A Croda Brand 810192C
Avanti
18:1-06:0 NBD PS, Avanti Research - A Croda Brand