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Merck
  • D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature.

D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature.

Clinical rheumatology (2011-10-13)
C U Manzini, M Sebastiani, D Giuggioli, A Manfredi, M Colaci, A M Cesinaro, C Ferri
摘要

Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia. Corticosteroids represent the first-line therapy, even if some patients are scarcely responsive and/or may develop important side effects due to long-term treatment. Here, we describe three cases of EF, two of them refractory to previous steroid therapy, successfully treated with D-penicillamine. The present clinical observations together with the updated review of the literature suggest usefulness of D-penicillamine in EF patients, as well as its potential steroid-sparing value.

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Sigma-Aldrich
D-青霉胺, 98-101%
青霉胺, European Pharmacopoeia (EP) Reference Standard