- New insights into ubiquitin E3 ligase mechanism.
New insights into ubiquitin E3 ligase mechanism.
Nature structural & molecular biology (2014-04-05)
Christopher E Berndsen, Cynthia Wolberger
PMID24699078
摘要
E3 ligases carry out the final step in the ubiquitination cascade, catalyzing transfer of ubiquitin from an E2 enzyme to form a covalent bond with a substrate lysine. Three distinct classes of E3 ligases have been identified that stimulate transfer of ubiquitin and ubiquitin-like proteins through either a direct or an indirect mechanism. Only recently have the catalytic mechanisms of E3 ligases begun to be elucidated.
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Sigma-Aldrich
L-赖氨酸 单盐酸盐, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
赖氨酸 盐酸盐, European Pharmacopoeia (EP) Reference Standard
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L-赖氨酸 单盐酸盐, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
L-赖氨酸 乙酸盐, European Pharmacopoeia (EP) Reference Standard