跳转至内容
Merck
  • [Management of opioid maintenance treatments when analgesic treatments are required].

[Management of opioid maintenance treatments when analgesic treatments are required].

Presse medicale (Paris, France : 1983) (2013-03-23)
Vincent Laprevote, Pierre A Geoffroy, Benjamin Rolland, Benoît F Leheup, Paolo Di Patrizio, Olivier Cottencin, Raymund Schwan
摘要

Opioid maintenance treatments (OMT) reduce illicit opiate use and its associated risks. They are often prescribed on a long-term basis. Physiological changes induced by long-term OMT may cause hyperalgesia and cross-tolerance to opioid agonists, which suggests that the dosage of analgesic treatment should be modified in cases of acute pain, especially when an opioid-based analgesia is required. When treatment with analgesics is necessary, OMT must be maintained, except in exceptional cases. If a split-dosing schedule is temporarily employed during OMT, the daily dosage should not be increased for analgesic purposes. Analgesic treatment must be managed differently in case of treatment with buprenorphine or methadone. With buprenorphine, non-opioid analgesics should be introduced first, if possible. If this strategy is inefficient or contraindicated, a temporary or definitive switch to methadone should be considered. In the case of methadone-based OMT, opioid analgesics should be added directly and the dosage should be adapted according to the level of pain reported by the patient.

材料
货号
品牌
产品描述

Supelco
丁丙诺啡标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
丁丙诺啡标准液 盐酸盐
Supelco
丁丙诺啡标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Supelco
丁丙诺啡 盐酸盐 溶液, analytical standard, for drug analysis