- Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters (2009-02-25)
Eduard Badarau, Franck Suzenet, Andrzej J Bojarski, Adriana-Luminiţa Fînaru, Gérald Guillaumet
PMID19237285
摘要
A new group of serotoninergic 5-HT(1A) or 5-HT(7) receptor ligands was identified. These compounds were designed and synthesized on a benzimidazolone scaffold and they enrich the well-known arylpiperazine class of 5-HT ligands. Diverse pharmacomodulations induced a shift in the affinity and selectivity profile with final identification of new potent hits.
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