V3265

VU0029767

≥98% (HPLC)

• 别名: (E)-2-(4-Ethoxyphenylamino)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide
• 经验公式（希尔记法）: C₂₁H₂₁N₃O₃
• CAS号: 326001-01-8
• 分子量: 363.41
• MDL號碼: MFCD01206089
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329829043

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: gray-brown
• 溶解度: DMSO: >10 mg/mL
• 儲存溫度: room temp
• SMILES 字串: CCOc1ccc(NCC(=O)N\N=C\c2c(O)ccc3ccccc23)cc1
• InChI: 1S/C21H21N3O3/c1-2-27-17-10-8-16(9-11-17)22-14-21(26)24-23-13-19-18-6-4-3-5-15(18)7-12-20(19)25/h3-13,22,25H,2,14H2,1H3,(H,24,26)/b23-13+
• InChI 密鑰: JWRJGCUSLSJMMD-YDZHTSKRSA-N

说明

生化／生理作用

VU0029767 is a selective, positive allosteric modulator at the muscarinic M1 acetylcholine receptor. It shifts concentration-dependent response to acetylcholine at least five-fold, but does not compete at the ACh binding site. VU0029767 also potentiates the effects of allosteric agonist TBPB.

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335,H410
• 防範說明: P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable