生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥50% (SDS-PAGE)
形狀
aqueous solution
分子量
115 kDa
包裝
pkg of 20 μg
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... RNF20(56254)
一般說明
Human ring finger protein 20, or RNF20 (GenBank Accession No. NM_019592) full length, amino acids 2-975 (end) with N-terminal His-Flag-tag, MW=115 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
外觀
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 20% glycerol and 3 mM DTT.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yosef Shiloh et al.
FEBS letters, 585(18), 2795-2802 (2011-08-11)
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand break (DSB). The DDR involves extensive
Efrat Shema et al.
Molecular cell, 42(4), 477-488 (2011-05-21)
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcribed
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