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Merck
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Key Documents

SML1039

Sigma-Aldrich

ENMD-1068 盐酸盐

≥97% (HPLC)

别名:

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride

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About This Item

经验公式(希尔记法):
C15H29N3O2 · HCl
分子量:
319.87
分類程式碼代碼:
51111800
NACRES:
NA.77

品質等級

化驗

≥97% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 25 mg/mL, clear

儲存溫度

2-8°C

InChI

1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3

InChI 密鑰

VRZYMMVEALDDBH-UHFFFAOYSA-N

應用

ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).

生化/生理作用

ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities.
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Caroline R C Costa et al.
International journal of molecular sciences, 19(8) (2018-08-17)
Snake venom serine proteases (SVSPs) represent an essential group of enzymatic toxins involved in several pathophysiological effects on blood homeostasis. Some findings suggest the involvement of this class of enzymatic toxins in inflammation. In this paper, we purified and isolated
Yifeng Wang et al.
American journal of obstetrics and gynecology, 210(6), 531-531 (2014-02-06)
Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model. A red fluorescent protein-expressing xenograft model

商品

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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