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化驗
≥98% (HPLC)
形狀
powder
顏色
light orange to dark orange
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
生化／生理作用
MONNA (benzbromarone (Benzb) and N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid) is a TMEM16A antagonists. It affects the liberation of sarcoplasmic reticulum (SR) calcium in human airway smooth muscle cells.
MONNA is a TMEM16A (ANO1) calcium-activated chloride channel blocker. MONNA blocks rhTMEM16A (ANO1) channel currents in HEK293 cells with and IC50 of 1.27 μM. The compound MONNA does not affect related human or mouse chloride channels bestrophin-1, CLC2 and CFTR at concentrations up to 10 μM.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium.
Danielsson J, et al.
Anesthesiology, 123(3), 569-581 (2015)
Quan-Fang Zhang et al.
Frontiers in plant science, 11, 145-145 (2020-03-13)
Ceramide sphingolipids are major components of membranes. C2 and C6 ceramides induce programmed cell death (PCD) in animals and plants, and we previously showed that C2 and C6 ceramides induce PCD in rice (Oryza sativa) protoplasts. However, the mechanistic link
Hayley Pearson et al.
Thorax, 76(1), 64-72 (2020-10-29)
Human respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious diseases for infants in developing countries. Of those infected, 25%-40% aged ≤1 year develop severe lower RTIs leading to
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