生物源
rat
品質等級
共軛
Atto 390 conjugate
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
23c, monoclonal
形狀
buffered aqueous solution
分子量
antigen predicted mol wt 60 kDa
物種活性
mouse, human, dog, rabbit, rat, hamster, bovine, sheep
濃度
1 mg/mL
技術
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同型
IgG2c
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Tcp1(21454)
一般說明
Tcp1 (t-complex protein ) is a chaperonin and a ATPase complex that encodes a chaperonin, localized to the cytosol.
免疫原
Purified recombinant mouse TCP1 alpha construct encoding the C-terminal half of the 1.8 kb full-length Tcp 1b gene expressed in E. coli. Detects the COOH group.
生化/生理作用
Tcp1 (t-complex protein) is involved in protein folding mechanism of essential proteins such as actins, tubulin, cyclin E, α-transducin and von Hippel Lindau protein. Tcp1 participates in synthesis of proteins that make up the cytoskeleton and thus involved in cellular processes such as chromosome segregation, cell migration, and intracellular transport. Increased TCP1 gene expression is observed in cancer and upregulation elevates with the disease progression.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
PBS pH7.4, 50% glycerol, 0.1% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Oncotarget, 6(39), 42105-42105 (2015)
The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Cell Stress & Chaperones, 21(1), 55-62 (2016)
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington?s disease.
Proceedings of the National Academy of Sciences of the USA, 113(38), E5655-E5664 (2016)
Investigative ophthalmology & visual science, 55(6), 3775-3785 (2014-05-24)
While some evidence suggests an essential role for the chaperonin containing t-complex protein 1 (CCT) in ciliogenesis, this function remains poorly understood mechanistically. We used transgenic mice, previously generated in our lab, and characterized by a genetically-induced suppression of CCT
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