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Merck
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Key Documents

SAB5201735

Sigma-Aldrich

Monoclonal Anti-Tcp1 Alpha - Atto 390 antibody produced in rat

clone 23c, purified immunoglobulin

别名:

Anti-AI528772, Anti-Ccta, Anti-Tric, Anti-p63

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rat

品質等級

共軛

Atto 390 conjugate

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

23c, monoclonal

形狀

buffered aqueous solution

分子量

antigen predicted mol wt 60 kDa

物種活性

mouse, human, dog, rabbit, rat, hamster, bovine, sheep

濃度

1 mg/mL

技術

immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG2c

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

mouse ... Tcp1(21454)

一般說明

Tcp1 (t-complex protein ) is a chaperonin and a ATPase complex that encodes a chaperonin, localized to the cytosol.

免疫原

Purified recombinant mouse TCP1 alpha construct encoding the C-terminal half of the 1.8 kb full-length Tcp 1b gene expressed in E. coli. Detects the COOH group.

生化/生理作用

Tcp1 (t-complex protein) is involved in protein folding mechanism of essential proteins such as actins, tubulin, cyclin E, α-transducin and von Hippel Lindau protein. Tcp1 participates in synthesis of proteins that make up the cytoskeleton and thus involved in cellular processes such as chromosome segregation, cell migration, and intracellular transport. Increased TCP1 gene expression is observed in cancer and upregulation elevates with the disease progression.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

PBS pH7.4, 50% glycerol, 0.1% sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Jiang X, et al.
Oncotarget, 6(39), 42105-42105 (2015)
The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Svanstrom A and Grantham J
Cell Stress & Chaperones, 21(1), 55-62 (2016)
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington?s disease.
Zhao X, et al.
Proceedings of the National Academy of Sciences of the USA, 113(38), E5655-E5664 (2016)
Satyabrata Sinha et al.
Investigative ophthalmology & visual science, 55(6), 3775-3785 (2014-05-24)
While some evidence suggests an essential role for the chaperonin containing t-complex protein 1 (CCT) in ciliogenesis, this function remains poorly understood mechanistically. We used transgenic mice, previously generated in our lab, and characterized by a genetically-induced suppression of CCT

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