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化驗
>98% (HPLC)
形狀
solid
顏色
white
溶解度
H2O: soluble 11 mg/mL
SMILES 字串
Br[H].Oc1ccc(cc1O)C2CNCc3sccc23
InChI
1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H
InChI 密鑰
QAIGGSDECIJPNW-UHFFFAOYSA-N
基因資訊
human ... DRD1(1812)
應用
SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.
生化/生理作用
SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.
D1 dopamine receptor agonist.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds
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