PZ0342

PF-6274484

≥98% (HPLC)

• 别名: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
• 经验公式（希尔记法）: C₁₈H₁₄ClFN₄O₂
• CAS号: 1035638-91-5
• 分子量: 372.78
• MDL號碼: MFCD30182370
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329823851
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to light brown
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: room temp
• SMILES 字串: FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32
• InChI: 1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
• InChI 密鑰: DTMQCGFVWWBONL-UHFFFAOYSA-N

说明

生化／生理作用

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC₅₀ values of 5.8 nM and 6.6 nM, respectively.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable