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Merck

PRS3969

Sigma-Aldrich

Anti-Sumo antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-GAP-modifying protein 1, Anti-SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae), Anti-Ubiquitin-like protein 1, Anti-small-ubiquitin-like modifier 1

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

mouse, human, rat

技術

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SUMO1(7341)

一般說明

SUMO1 (small ubiquitin-related modifier) is also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin. It is located in the nucleus. It is located in chromosome 2q33.
SUMO1 (small ubiquitin-related modifier) is also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin. It is located in the nucleus. SUMO1 gene is located on human chromosome 2q33.

免疫原

a 14 amino acid peptide from near the amino-terminus of human sumo.

生化/生理作用

Suppressing SUMO1 (small ubiquitin-related modifier) stops multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It involves in mitochondrial fission.
Suppressing SUMO1 (small ubiquitin-related modifier) stops multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It is involved in mitochondrial fission.

聯結

The action of this antibody can be blocked using blocking peptide SBP3969.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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价格

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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SUMO1 depletion prevents lipid droplet accumulation and HCV replication
Akil A, et al.
Archives of Virology, 161(1), 141-148 (2016)
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission
Harder Z, et al.
Current Biology, 14(4), 340-345 (2004)
The genetic basis of cleft lip and cleft palate
Veros C, et al.
Aristotle University Medical Journal, 43 (2016)
The nucleoporin RanBP2 has SUMO1 E3 ligase activity
Pichler A, et al.
Cell, 108(1), 109-120 (2002)
SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells
Jin L, et al.
Cellular Physiology and Biochemistry, 41(3), 987-998 (2017)

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