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Merck

I2765

Sigma-Aldrich

鹅膏氨酸

~95% (TLC), solid, neurotoxin

别名:

α-氨基-3-羟基-5-异噁唑乙酸

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About This Item

经验公式(希尔记法):
C5H6N2O4
CAS号:
分子量:
158.11
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32

product name

鹅膏氨酸, ~95%, solid

化驗

~95%

形狀

solid

顏色

white

溶解度

H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL

SMILES 字串

NC(C(O)=O)C1=CC(=O)NO1

InChI

1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

InChI 密鑰

IRJCBFDCFXCWGO-UHFFFAOYSA-N

基因資訊

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應用

鹅膏蕈氨酸作为神经毒素用于大鼠。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术,以研究逆转增强剂诱导的发声变化。

生化/生理作用

对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。
鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体,破坏丘脑网状核(NRT)。它能诱导大量钙离子流入,导致神经元损伤。由于其具有兴奋性毒性功能,鹅膏蕈氨酸用于诱导产生神经退行性变。

注意

吸湿

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

防範說明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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