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Merck

D5412

Sigma-Aldrich

2′-脱氧尿苷

≥98.5%

别名:

1-(2-脱氧-β-D-呋喃核糖基)尿嘧啶, 尿嘧啶脱氧核苷

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About This Item

经验公式(希尔记法):
C9H12N2O5
CAS号:
分子量:
228.20
Beilstein:
24433
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥98.5%

形狀

powder

雜質

Thymidine, free

溶解度

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES 字串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

InChI 密鑰

MXHRCPNRJAMMIM-SHYZEUOFSA-N

基因資訊

mouse ... Slc29a1(63959)

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應用

2′-脱氧尿苷已用于:
  • 代替胸苷用作[3H]胸苷三磷酸 (TTP)前体,避免在相对增殖测定中潜在的胸苷阻断
  • 用作核苷补充剂,以进行细胞周期同步和DNA复制抑制
  • 用作培养基中的有丝分裂抑制剂,最大限度减少神经胶质细胞增殖

生化/生理作用

2′-脱氧尿苷(dU)经常被卤化,生成用于DNA合成和降解机制研究的胸苷激酶类似物。作为标记底物的衍生2′-脱氧尿苷包括氯-2′-脱氧尿苷(CldU)、溴脱氧尿苷(BrdU)和/或碘脱氧尿苷(IdU)。其他有用的2′-脱氧尿苷类似物包括5-乙基-2′-脱氧尿苷(DdU)和5-羟基甲基-2′-脱氧尿苷(HmdU)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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