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Merck
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文件

C1613

Sigma-Aldrich

羧苄西林

Ready Made Solution, 100 mg/mL in ethanol/water, 0.2 μm filtered

别名:

α-羧苄青霉素 溶液

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About This Item

经验公式（希尔记法）:
C17H18N2O6S
分子量:
378.40
MDL號碼:
MFCD00242604
分類程式碼代碼:
51282404
PubChem物質ID:
24892425
NACRES:
NA.85

無菌

0.2 μm filtered

形狀

liquid

濃度

100 mg/mL in ethanol/water

溶解度

H2O: 100 mg/mL
ethanol: 100 mg/mL

適合性

suitable for testing specifications (Bacteriostatic (cell type) E. Coli DH5a, result: pass)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

CC1(C)S[C@@H]2[C@H](NC(=O)C(C(O)=O)c3ccccc3)C(=O)N2[C@H]1C(O)=O

InChI

1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/t9?,10-,11+,14-/m1/s1

InChI 密鑰

FPPNZSSZRUTDAP-UWFZAAFLSA-N

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相关类别

一般說明

化学结构:β-内酰胺

應用

羧苄青霉素(Carbenicillin)可用于筛选氨苄青霉素抗性转化细胞。还可用于研究青霉素敏感的转肽酶在细胞壁生物合成中的作用。

生化／生理作用

羧苄西林(Carbenicillin)是一种氨苄西林类似物，具有苄基青霉素结构。羧苄西林可有效抑制革兰氏阴性菌，对革兰氏阳性菌也有一定的抑制作用。羧苄西林结合并抑制参与细菌细胞壁合成的酶。由于羧苄西林对β-内酰胺酶的敏感性弱于氨苄西林，它可有效抑制氨苄西林抗性细菌。在低pH条件下具有优越的稳定性，可发挥筛选功能。 羧苄西林的有效浓度：50-100 μg/ml。

其他說明

保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。

象形圖

FlameHealth hazard
GHS02,GHS08

訊號詞

Danger

危險聲明

H226,H317,H334

危險分類

Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

104.0 °F - closed cup

閃點（°C）

40 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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G N Rolinson
The Journal of antimicrobial chemotherapy, 41(6), 589-603 (1998-08-01)
For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6-aminopenicillanic acid.
A J Wright
Mayo Clinic proceedings, 74(3), 290-307 (1999-03-25)
The penicillin family of antibiotics remains an important part of our antimicrobial armamentarium. In general, these agents have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections caused by susceptible bacteria. The initial introduction of aqueous
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Antimicrobial agents and chemotherapy, 54(5), 2239-2243 (2010-03-10)
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps
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Antimicrobial agents and chemotherapy, 54(5), 2219-2224 (2010-03-03)
Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance.
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