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生物源
human
品質等級
重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
626-848 nmol/min·mg
分子量
A1 subunit ~68 kDa
B1 subunit ~38 kDa
G1 subunit ~40 kDa
溶解度
water: soluble
應用
life science and biopharma
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PRKAA1(5562) , PRKAB1(5564) , PRKAG1(5571)
一般說明
研究领域：细胞信号传导
AMP活化蛋白激酶（AMPK）是一种异源三聚体蛋白激酶，由α催化亚基、非催化β亚基和γ亚基组成。
AMP活化蛋白激酶（AMPK）是一种异源三聚体蛋白激酶，由α催化亚基、非催化β亚基和γ亚基组成。
應用
AMP活化蛋白激酶（AMPK）可用于通过生物层干涉（Bio-Layer Interferometry，BLI）结合测定，评估芬氏唐松草碱（thalidezine）与重组活性人 AMPK的结合动力学。(1)
生化／生理作用
AMP活化蛋白激酶（AMPK）是一种重要的能量感应酶（energy-sensing enzyme），可监测细胞能量状态。响应细胞代谢应激，AMPK被激活并磷酸化和灭活乙酰辅酶A羧化酶（ACC）和3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR），这是调节脂肪酸和胆固醇生物合成的关键酶。
外觀
50 mM 磷酸氢二钠 pH 7.0、300 mm NaCl、150 mm 咪唑、0.1 mM PMSF、0.2 mm DTT、25% 甘油中提供。
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death
Law BTK
Oncotarget, 8(18), 30077?30091-30077?30091 (2017)
D G Hardie et al.
European journal of biochemistry, 246(2), 259-273 (1997-06-01)
A single entity, the AMP-activated protein kinase (AMPK), phosphorylates and regulates in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase (key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively), and probably many additional targets. The kinase is activated by high
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig S and Shaw RJ
Nature Reviews in Molecular and Cell Biology, 19, 121?135 -121?135 (2018)
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Yasuhiko Minokoshi et al.
Nature, 428(6982), 569-574 (2004-04-03)
Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a 'fuel gauge' to monitor cellular energy status. We investigated
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