推荐产品
product name
来曲唑, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >50 mg/mL
起源
Novartis
儲存溫度
2-8°C
SMILES 字串
N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI
1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI 密鑰
HPJKCIUCZWXJDR-UHFFFAOYSA-N
基因資訊
human ... CYP19A1(1588)
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應用
来曲唑已用于：
- 在类器官生长试验中测定其抑制力（48）
- 研究类固醇受体共激活因子1（SRC-1）介导的海马PSD-95内源性雌激素调节作用（49）
- 研究其对肿瘤诱导的痛觉过敏的作用 （50）
- 对大鼠进行激素干预（51）研究其对脂质运载蛋白-2（Lcn2）的作用（52）研究其对机械痛觉过敏和芳香化酶表达的作用（53）
生化／生理作用
来曲唑是一种佐剂，可用于治疗乳腺癌。
来曲唑是第三代非甾体芳香酶抑制剂。 它是芳香酶系统的竞争性抑制剂，因此可抑制雄激素向雌激素转化。来曲唑通过竞争性结合到该酶的细胞色素P450亚基的血红素上而抑制芳香酶，导致所有组织中雌激素的生物合成减少。
訊號詞
Warning
危險聲明
危險分類
Repr. 2 - STOT RE 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Despite prevalence of polycystic ovary syndrome (PCOS) among childbearing women and development of many animal models for this syndrome, information on its etiology is still scarce. The intrauterine hyperandrogenic environment may underlie changes at the level of hypothalamus, pituitary, ovary
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