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Merck
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主要文件

477R-1

Sigma-Aldrich

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

别名:

Melanoma-associated antigen C2

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP405, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (477R-14)
vial of 0.1 mL concentrate Research Use Only (477R-14-RUO)
vial of 0.5 mL concentrate (477R-15)
vial of 1.0 mL concentrate (477R-16)
vial of 1.0 mL concentrate Research Use Only (477R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (477R-17)
vial of 7.0 mL pre-dilute ready-to-use (477R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同位素/亚型

IgG

控制

seminoma

运输

wet ice

储存温度

2-8°C

可视化

nuclear

一般描述

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.4 In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.5-7

质量

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000388089
0000388089

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Yao-Tseng Chen et al.
Human reproduction (Oxford, England), 26(12), 3232-3243 (2011-10-22)
Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined. The expression of 10 CT-X antigens (MAGEA, NY-ESO-1
Peter K Bode et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 829-835 (2011-07-23)
Melanoma-associated gene C2 (MAGEC2) is a recently identified cancer testis antigen expressed in normal testicular and placental tissue. It has been detected in some human carcinomas, but its expression in primary testicular germ cell tumors is unknown. Immunohistochemistry was used
Annikka Weissferdt et al.
Human pathology, 46(3), 376-383 (2015-01-13)
Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This
Ran Zhuang et al.
Cancer immunity, 6, 7-7 (2006-04-06)
CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In
Anna K Lee et al.
Journal of molecular biology, 429(8), 1114-1142 (2017-03-17)
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more
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