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27689

Sigma-Aldrich

刀豆素A

from Streptomyces sp., ≥80% (HPLC)

别名:

福霉素

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About This Item

经验公式（希尔记法）:
C46H75NO14
CAS号:
80890-47-7
分子量:
866.09
Beilstein:
3560277
MDL號碼:
MFCD00210037
分類程式碼代碼:
12352200
PubChem物質ID:
329753012
NACRES:
NA.25

生物源

Streptomyces sp.

化驗

≥80% (HPLC)

形狀

solid

抗生素活性譜

viruses

作用方式

enzyme | inhibits

儲存溫度

−20°C

SMILES 字串

CCC1C(O)C(C)C\C(C)=C\C=C\C(OC)C(OC(=O)\C(OC)=C\C(C)=C\C(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)\C=C\C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1

InChI 密鑰

DJZCTUVALDDONK-LWLXYWDNSA-N

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一般說明

Chemical structure: macrolide

應用

Concanamycin A has been used as an inhibitor of the perforin pathway.

其他說明

Characterization of concanamycins A, B and C; Selective inhibitor of the vacuolar proton-ATPase.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

儲存類別代碼

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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R Guinea et al.
FEBS letters, 349(3), 327-330 (1994-08-08)
The selective inhibitor of the vacuolar proton-ATPase, concanamycin A, powerfully blocks influenza virus entry into cells, if present during the initial times of virus infection. Attachment of virus particles to cells is not prevented by concanamycin A, rather the exit
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c.
Huss M
The Journal of Biological Chemistry, 277(43), 40544-40548 (2002)
Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies
P. C. Kuechler
Allergy (2004)
H. Kinashi et al.
The Journal of Antibiotics, 38, 1333-1333 (1984)
Wucheng Tao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3738-3743 (2013-03-01)
Ambient GABA in the brain tonically activates extrasynaptic GABA(A) receptors, and activity-dependent changes in ambient GABA concentration can also activate GABA(B) receptors. To investigate an interaction between postsynaptic GABA(B) and GABA(A) receptors, we recorded GABA(A) currents elicited by exogenous GABA
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