推荐产品
生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
SP17, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (229R-14)
vial of 0.5 mL concentrate (229R-15)
bottle of 1.0 mL predilute (229R-17)
vial of 1.0 mL concentrate (229R-16)
bottle of 7.0 mL predilute (229R-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同型
IgG
控制
medullary carcinoma of thyroid
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
cytoplasmic
一般說明
Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism. It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin. Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid3,4 and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.
Immunohistochemical staining with anti-calcitonin antibody has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities. citationcitationcitationcitationcitation
Immunohistochemical staining with anti-calcitonin antibody has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities. citationcitationcitationcitationcitation
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Calcitonin Positive Control Slides, Product No. 229S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Y Kameda et al.
Cell and tissue research, 206(3), 403-415 (1980-01-01)
The development of C-cell complexes was investigated in dog fetuses by an immunoperoxidase method with three specific antisera: anti-calcitonin, anti-C-thyroglobulin (C-Tg), and anti-19S thyroglobulin. Ultimobranchial bodies joined with the thyroid anlage and then dispersed into the parenchyma to form large
Y Dayal et al.
Cancer, 43(4), 1331-1338 (1979-04-01)
A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci of calcitonin-producing
Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium.
D H COPP et al.
Endocrinology, 70, 638-649 (1962-05-01)
Plasma-immunoreactive-calcitonin in patients with non-thyroid tumours.
R C Coombes et al.
Lancet (London, England), 1(7866), 1080-1083 (1974-06-01)
Calcitonin and carcinoembryonic antigen as tumor markers in medullary thyroid carcinoma.
R A DeLellis et al.
American journal of clinical pathology, 70(4), 587-594 (1978-10-01)
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