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生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
12H6.1, monoclonal
物種活性
human
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... NINJ1(4814)
一般說明
Ninjurin-1 (UniProt Q92982; also known as Nerve injury-induced protein 1) is encoded by the NINJ1 (also known as NIN1, NINJURIN) gene (Gene ID 4814) in human. Ninjurin-1 (NINJ1) is a cell surface adhesion molecule originally identified to be up-regulated in neuronal and Schwann cells after sciatic nerve injury. NINJ1 is also reported to play a role in the progression of multiple sclerosis, an autoimmune inflammatory CNS disease characterized by demyelination and axonal damage. In addition, NINJ1 is known to cause regression of hyaloid blood vessels important for the maturation of the lens during embryonic development. Consistent with the latter role in vascular system, Penile injection of Ninj1-neutralizing antibody is shown to significantly restore erectile function in a murine model of diabetic erectile disfunction (ED) as a result of enhanced cavernous endothelial cell proliferation. Human Ninjurin-1 is a 152-amino aicd protein with boht its N- and C-terminal ends exposed extracellulary (a.a. 1-80, 142-152) and a short intracellular segment (a.a. 102-119) sandwiched between two transmembrane domains (a.a. 81-101, 121-141).
特異性
Clone 12H6.1 targets the N-terminal extracellular domain of human Ninjurin-1.
免疫原
Epitope: N-terminal extracellular domain.
GST-tagged recombinant human Ninjurin-1/NINJ1 N-terminal extracellular domain.
應用
Anti-Ninjurin-1 Antibody, clone 12H6.1 is an antibody against NINJ1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NINJ1 in human liver, pancreas and cerebral cortex tissue sections.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
品質
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected NINJ1 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected NINJ1 in 10 µg of HeLa cell lysate.
標靶描述
~17 kDa observed. 16.35 kDa calculated.
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Shanshan Wang et al.
PLoS pathogens, 18(3), e1010415-e1010415 (2022-03-19)
A hallmark of Entamoeba histolytica (Eh) invasion in the gut is acute inflammation dominated by the secretion of pro-inflammatory cytokines TNF-α and IL-1β. This is initiated when Eh in contact with macrophages in the lamina propria activates caspase-1 by recruiting
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