生物源
rabbit
品質等級
抗體表格
unpurified
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
rat
包裝
antibody small pack of 25 μL
技術
immunohistochemistry: suitable (paraffin)
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
ambient
目標翻譯後修改
unmodified
基因資訊
rat ... Ptprz1(25613)
一般說明
Receptor-type tyrosine-protein phosphatase zeta (UniProt: Q62656; also known as EC:3.1.3.48, R-PTP-zeta, 3F8 chondroitin sulfate proteoglycan, 3H1 keratan sulfate proteoglycan, Phosphacan) is encoded by the Ptprz1 (also known as Ptprz, Ptpz) gene (GeneID: 25613) in rat. It is a soluble nervous tissue-specific proteoglycan that is thought to regulate axonal outgrowth. It is synthesized by glia and binds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM but not to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth and negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. It is required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. RPTPzeta has an extracellular domain (aa 25-1637), a transmembrane domain (aa 1638-1663) and a cytoplasmic domain (aa 1664-2316). It is produced with a signal peptide (aa 1-24) that is cleaved to generate the mature form.
特異性
This rabbit polyclonal antibody specifically detects PTP zeta/Phosphacan in rat brain tissue.
免疫原
Epitope: unknown
Full length (aa 1-2316) purified Receptor-type tyrosine-protein phosphatase zeta (Phosphacan) isolated from 7-day fetal rat brain.
應用
Anti-phosphacan, Cat. No. ABN2246 is a rabbit polyclonal antibody that has been tested for use in Immunohistochemistry (Paraffin) for the detection of Receptor-type tyrosine-protein phosphatase zeta.
Immunohistochemistry Analysis: A representative lot detected PTP zeta/Phosphacan in E16 rat spinal cord (Milev, P., et. al. (1994). J Cell Biol. 127(6 Pt 1):1703-15), rat brain (Haunso, A., et. al. (1999). Brain Res. 834(1-2):219-22), and 21-day postnatal rat retina, 2-week postnatal rat cerebellum, E13 rat spinal cord (Milev, P., et. al. (1998). J Biol Chem. 273(12):6998-7005).
Research Category
Cell Structure
Cell Structure
品質
Evaluated by Immunohistochemistry (Paraffin) in rat cerebral cortex and rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected PTP zeta/Phosphacan in rat cerebral cortex and rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected PTP zeta/Phosphacan in rat cerebral cortex and rat hippocampus tissue.
標靶描述
255.34 kDa calculated.
外觀
Unpurified
Format: Unpurified
Rabbit polyclonal antiserum with 0.02% sodium azide.
Rabbit polyclonal antiserum with 0.02% sodium azide.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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